A single-nucleotide polymorphism (SNP's, so pronounced snips) is a DNA sequence variation occurs where a single nucleotide A, T, C, or G in the genome differs between members of a biological species or paired chromosomes in an individual.genes are interconnected via a variety of gene interactions. Single nucleotide polymorphisms are frequently associated with human phenotypes, and SNPs in different genes that are strongly correlated with each other may be important for gene interactions. Therefore, exploring the linkages between SNPs may offer new insights into the biological interactions in the human molecular system.For example, two sequenced DNA fragments from different individuals, AAGCCTA to AAGCTTA, contain a difference in a single nucleotide. In this case we say that there are two alleles: C and T. Almost all common SNPs have only two alleles. Within a population, SNPs can be assigned a minor allele frequency the lowest allele frequency at a locus that is observed in a particular population. This is simply the lesser of the two allele frequencies for single-nucleotide polymorphisms. There are variations between human populations, so a SNP allele that is common in one geographical or ethnic group may be much rarer in another .Unlike non-synonymous, here we're describing and characterizing the Synonymous SNPs in Human.
|chrom. no.||variation id||ensembl id||variant allele||conseq type|